History of Nootropil (Piracetam)

Piracetam has been developed by Corneliu E. Giurgea a Romanian chemist, in the year 1964. It was made by convert 2-pyrrolidinone into the amide. Nootropil was the first racetam has a very long history of uses in medical area and developed. Although it is often found to have medical advantages, it is used off label as a nootropic and is not filed in North America.
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Mechanism of Activity

The mechanism of activity of piracetam isn't completely comprehended. It's a cyclic derivative of GABA metabolism and GABA receptors seem to not be changed. It's a stimulant, a sedative or neither but is understood to affect cognitive capacity. Piracetam is, in addition, considered to be a circulatory agent and a vasodilator but this isn't considered to be its primary nootropic activity.

The general consensus is that Piracetam affects the AMPA and NMDA receptor sites. These receptors are essential in learning and memory processes. It's also understood that it changes the ACh receptor sites and the Acetylcholine neurotransmitter. General Neurotransmission appears to be enhanced and this is considered to be due to modulation of carrier waves or ion channels.

Piracetam Uses (Medical)

Piracetam is administered for a wide variety of functions and is used in some states as a medical agent. Venezuela's main medical use is as a neuro-protective agent before or after stroke. The material is considered to decrease the risk of ischemic stroke in addition to reduce post-stroke damage to the brain. It's additionally an antithrombotic and anticoagulant agent that is frequently used security in conjunction with the other treatments.

There have been many studies on treatment with Piracetam for neurological disorders. Several of these studies show favorable results but not enough to approve them as treatments in the medical area. For example, there's been evidence in studies for effectiveness in improving symptoms in Alzheimer's and Dementia patients. Although, symptoms for these patients were regularly improved, it isn't an accepted treatment because it hasn't been demonstrated to completely reverse the states or take the position of treatments and other authorized drugs.

For these reasons, Piracetam is used mostly off-label. It's proven to be pretty safe, with low toxicity, side effects and drug interactions. Evidence reveals it may have in treating a host of neurological disorders and learning disabilities and symptoms of Dyslexia cogency, but this must not be relied on as treatment without consultation of a licensed medical practitioner.

Piracetam Advantages

Piracetam was used for decades as an off label nootropic agent. It's been found to be successful in raising: reaction times and memory and cognition, learning, focus but these results appear to change. Below are a few of the gains which were reported off label and in medical studies.

  • Increased Memory;
  • Enhanced Learning;
  • Greater Focus;
  • Heightened Sensory Function;
  • Decreased Stress/Depression;
  • Improved Vasodilation;
  • Decreased Brain Injury.

One advantage that's been extensively reported is a rise in sensory awareness. This is probably as a result of the Increase in receptor efficiency and the Acetylcholine neurotransmitter. Many people say Piracetam is successful as an antidepressant agent but hasn't been approved as a treatment. It may have anti- depressant and stress gains in some users.

Piracetam, along with other racetams have been mentioned to act as a brain protectant but shouldn't serve as a main protective agent. These effects might or might not be due to vasodilation that was improved. Piracetam is considered to reduce free radicals in the brain. Oxidative stress can be a cause of cholinergic damages that can lead to Dementia and Alzheimer's along with other neurological disorders.

Piracetam Security, Drug Interactions & Tolerance

Piracetam was demonstrated to have quite small side effects and drug interactions. Side effects can happen but this is generally not unusual in people who are sensitive to the material or in higher doses. There's been limited data to indicate Piracetam has resulted in serious health complications or fatalities. Below are a few of the common side effects.

  • Head Aches;
  • Nausea;
  • Exhaustion;
  • Sleeplessness;
  • Gastrointestinal Problems;
  • Melancholy.

A few of these common cognitive side effects are theorized to be caused by ACh receptor site "burn out". This is reported to be reduced by supplementation with a choline source, like CDP Choline or Alpha GPC. This is if you experience these side effects it's a good idea to discontinue use and seek medical counsel guidance and only a theory.

Drug interactions with Piracetam appear to be restricted. If you're on any other medicine, always consult a physician prior to use and avoid using higher than recommended dosages. Piracetam shouldn't been relied on as a treatment for any medical condition that is serious.

Piracetam is sold under a large selection of brand names. Popular trade names for piracetam in Europe are Lucetam and Nootropil, among many others. In Argentina, it's made by GlaxoSmithKline S.A. lab's and sold under the trade name of Noostan (800 mg or 1200 milligrams). In Venezuela and Ecuador, piracetam is made by Laboratorios Farma S.A. and sold under the brand name Breinox. In Mexico is made by UCB de Mexico, and sold under the brand name of Nootropil. Other names contain Nootropil in the U.S., Europe, Hong Kong, Brazil, Mexico and India; Lucetam, Smart, Oikamid, Geratam, Brazil and Biotropil in Europe and; Neurobasal in Colombia; Breinox in Ecuador and Venezuela; Noostan in Argentina; Stimulan in Egypt; and Nocetan in Latin America.

Allowance with the material appears quite low. Frequently, the material can be taken for months with no notice of endurance develop but this can change. Endurance hasn't been demonstrated to lead to unpleasant withdrawal symptoms but this can change and should constantly be assessed. Some racetam users will "cycle" Piracetam to reduce endurance.

Piracetam was first synthesized in 1964 by scientists at the Belgian pharmaceutical company UCB directed by Dr Corneliu E. Giurgea; struck by its evident skill to foster mental functioning in even healthy people and by its security, Giurgea coined the term nootropic to describe it and other materials. Piracetam (trade name "Nootropil") was established clinically by UCB in the early 1970s, and now is in use in many European nations.

Piracetam Stack

Piracetam goes nicely in combination with other nootropics. This mixture is frequently called a nootropic stack. It goes nicely with a choline source and this is consistently advocated. Piracetam also stacks well with all the other racetams. Some pick to pile it with other racetams or ones that are chosen. One edge is it is pretty inexpensive as compared to other racetam Piracetam. Nootropics and Aniracetam is a great stack is a mix that is very affordable